Michigan quarterback J.J. McCarthy runs from Iowa defensive lineman Lukas Van Ness in the second half of the Wolverines’ 27-14 win on Saturday in Iowa City, Iowa. Charlie Neibergall/Associated Press

IOWA CITY, Iowa — Blake Corum rushed for 133 yards and a touchdown, J.J. McCarthy threw for 155 yards and a touchdown and No. 4 Michigan defeated Iowa 27-14 on Saturday.

The Wolverines (5-0, 2-0 Big Ten Conference) were able to consistently move the ball against the Hawkeyes (3-2, 1-1), who came into the game leading the nation in scoring defense and ranked sixth in total defense and rushing defense. Michigan had 327 yards, including 172 rushing yards.

Four of Michigan’s first five drives ended in points. Ronnie Bell had a 16-yard touchdown run on the opening possession. Jake Moody’s two second-quarter field goals gave the Wolverines a 13-0 halftime lead, then McCarthy threw a 12-yard touchdown pass to Donovan Edwards on Michigan’s opening possession of the third quarter.

Bell’s run finished an 11-play, 75-yard drive that took more than five minutes off the clock.

(2) ALABAMA 49, (20) ARKANSAS 26: After Bryce Young was knocked out of the game with a shoulder injury in the second quarter, the Crimson Tide (5-0, 2-0 SEC) turned to Jahmyr Gibbs and backup quarterback Jalen Milroe to pull away from the Razorbacks (3-2, 1-2) in Fayetteville, Arkansas.

Young left with 10:34 remaining in the second quarter with what Coach Nick Saban called a sprained right, throwing shoulder and did not return. Young was on the sideline in uniform for the second half.

Alabama led 14-0 when Young was hurt. Milroe led Alabama to touchdowns on his first two drives to open a 28-0 lead.

No. 20 Arkansas scored the next 23 points and held the Alabama offense, missing Young, to minus-1 yard in the third quarter.

Young won the Heisman Trophy last year, throwing for 4,872 yards and 47 touchdowns.

(3) OHIO STATE 49, RUTGERS 10: Miyan Williams carried the load for No. 3 Ohio State, rushing for a career-high 189 yards and five touchdowns as the Buckeyes (5-0, 2-0 Big Ten) beat the Scarlet Knights  (3-2, 0-2) in Columbus, Ohio.

Williams got the opportunity for a career-high 21 carries when TreVeyon Henderson became a late scratch because of an unspecified injury. Williams, a third-year back, exploded for a 70-yard TD romp in the third quarter and also had four short scoring plunges.

A 2-yard TD in the fourth quarter, his fifth of the game, tied an Ohio State record. He’s the first back to rush for five touchdowns in a game since Keith Byars in 1984. Pete Johnson also did it in 1974.

Williams stepped up with the best game of his Ohio State career on a day when quarterback C.J. Stroud wasn’t as sharp as usual. The Heisman Trophy favorite completed 13 of 22 passes for a career-low 154 yards with two touchdown and an interception.

(9) OKLAHOMA STATE 36, (16) BAYLOR 25: Jaden Nixon returned the second-half kickoff 98 yards for a touchdown, and the Cowboys (4-0, 1-0 Big 12) beat the Bears (3-2, 1-1 Big 12) in Waco, Texas in a rematch of last year’s Big 12 championship game.

Nixon’s return started a flurry of 39 combined points in the third quarter. He found an open gap in the middle of the field and then broke free from the grasp of Devyn Bobby at the Oklahoma State 35.

Oklahoma State quarterback Spencer Sanders continued his outstanding play. He finished 20-of-29 passing for 181 yards with a touchdown and an interception and ran 14 times for 75 yards.

The Cowboys (4-0, 1-0 Big 12) also beat Baylor in the regular season last year, but came up inches short of their first conference title since 2011 when the Bears made a fourth-down stop just short of the end zone in the final seconds of the championship game.

(14) MISSISSIPPI 22, (7) KENTUCKY 19: Austin Keys and Jared Ivey each forced fumbles in the final three minutes, both inside the red zone, and the Rebels (5-0, 1-0 SEC) held off the Wildcats (4-0, 1-1) in Oxford, Mississippi.

Keys and Ivey forced Wildcats quarterback Will Levis to fumble on consecutive possessions with AJ Finley and Tavius Robinson recovering both, respectively. Both plays stopped potential game-winning drives inside the 20 to preserve the victory for the Rebels (5-0, 1-0 Southeastern Conference).

Jonathan Cruz’s go-ahead, 26-yard field goal late in the third quarter put Ole Miss up 22-19 and set the stage for the tense, frantic finish. The Rebels’ defense first forced the Wildcats to turn over the ball over on downs early in the fourth before creating the turnovers to seal the win.

Levis led Kentucky (4-0, 1-1) to the Ole Miss 18 before fumbling while diving for additional yardage. The Wildcats created a final opportunity on Levis 51-yard pass to Barion Brown to the 7. After a touchdown-nullifying illegal motion penalty, Levis fumbled on the next play on a sack by Ivey with 58 seconds remaining.

(11) PENN STATE 17, NORTHWESTERN 7: Nick Singleton had 21 carries for 87 yards and a touchdown, Penn State’s defense forced three turnovers and the Nittany Lions (5-0, 2-0 Big Ten) outlasted the Wildcats (1-3, 1-1) in State College, Pennsylvania.

Sean Clifford completed 10 of 20 passes for 140 yards with a touchdown and Kaytron Allen added 86 rushing yards on 21 carries to help Penn State stay unbeaten heading into an off week.

Both teams struggled early, combining for six turnovers in the first half after heavy rain drenched Beaver Stadium just before kickoff.

Penn State coughed up the ball twice on its first three drives. Xander Mueller recovered a Singleton fumble and Bryce Gallagher intercepted Clifford, but Penn State’s defense kept the Wildcats from taking advantage.

TCU 55, (18) OKLAHOMA 24: Max Duggan ran 67 yards for one of two touchdowns and threw for three scores, leading the Horned Frogs (4-0, 1-0 Big 12)  to a rout of Oklahoma (3-2, 0-2) in a second consecutive loss for new Sooners coach Brent Venables, in Fort Worth, Texas.

OU quarterback Dillon Gabriel was knocked out of the game in the second quarter when he was hit while sliding by TCU linebacker Jamoi Hodge, who was ejected for targeting.

Players had to be separated after Hodge’s hit while Gabriel stayed down for several minutes, surrounded by the medical staff, before the UCF transfer walked off the field on his own. Pittsburgh transfer Davis Beville replaced him.

PURDUE 20, (21) MINNESOTA 10: Devin Mockobee rushed for 102 yards and a late touchdown to pad Purdue’s lead, and the Boilermakers defense fueled yet another takedown of a ranked opponent in a victory over the Golden Gophers (4-1, 1-1) in Minneapolis.

Cam Allen had two of Purdue’s three interceptions of Tanner Morgan, one in the end zone in the second quarter and another in the closing minutes. Quarterback Aidan O’Connell returned from a one-game injury absence for the Boilermakers and bounced back from two first-half interceptions to direct two drives for scores in the final 5 minutes.

(22) WAKE FOREST 31, (23) FLORIDA STATE 21: Sam Hartman threw for 234 yards and two touchdowns, Justice Ellison ran for 114 yards and a touchdown and the Demon Deacons (4-1, 1-1 ACC) beat the Seminoles (4-1, 2-1) in Tallahassee, Florida.

Wake Forest ran for 171 yards and bounced back from its double-overtime loss to No. 5 Clemson. Hartman connected with eight receivers, with A.T. Perry leading the way with eight receptions for 91 yards and a touchdown.

The Demon Deacons also converted 7 of 11 third downs and 2 of 2 fourth downs as they took a 21-7 lead at the half.

Jordan Travis connected with Mycah Pittman on touchdown receptions of 18 and six yards as the Seminoles opened both halves with TD drives. Travis completed 23 of 35 passes for 281 yards and three touchdowns.

The Seminoles got within 28-21 with a 58-yard drive in the fourth quarter, which culminated in Travis’ 4-yard TD throw to Johnny Wilson and a two-point pass. But the Demon Deacons responded again with a long drive, ending in Matthew Dennis’ 27-yard field goal to give them a 31-21 lead with 2:55 left.

(25) KANSAS STATE 37, TEXAS TECH 28: Adrian Martinez rushed for 171 yards and three touchdowns and threw for another score, leading the Wildcats (4-1, 2-0 Big 12) past the Red Raiders (3-2, 1-1) in Manhattan, Kansas.

Martinez was 12-for-19 passing for 116 yards for Kansas State, while Deuce Vaughn had 170 rushing yards for the Wildcats, who extended their winning streak against the Red Raiders to seven games.

Donovan Smith was 34-for-48 passing for 359 yards and two TDs for Texas Tech. Smith also rushed for a touchdown.

BOSTON COLLEGE 34, LOUISVILLE 33: Phil Jurkovec threw for 304 yards and three touchdowns and scrambled for a 33-yard run that set up the game-winning field goal as the Eagles (2-3, 1-2 ACC) knocked Louisville quarterback Malik Cunningham out of the game and beat the Cardinals (2-3, 0-3) in Boston.

Cunningham ran for three touchdowns and threw for another before finishing the game on the sideline. He was taken out for one play in the third quarter following a hit to the head; he came back for two full series before backup Brock Domann handled the last two possessions of the game.

The second, after Connor Lytton’s 26-yard field goal gave BC the lead with 1:56 left, ended where it started after four straight incompletions.

Boston College then ran out the clock — or tried to. With 2 seconds left for the fourth down play, Jurkovec took several steps back before kneeling and the time showed 0:00.