Muhammad Ali is hospitalized in the Phoenix area with what two people familiar with his condition say may be more serious problems than his previous hospital stays.

The 74-year-old boxing great is fighting respiratory issues that are complicated by the Parkinson’s that he was diagnosed with in the 1980s, the people told The Associated Press on Thursday.

The two spoke separately in describing Ali’s condition that they say is concerning to family members. They declined to be identified because they were not speaking on behalf of the family.

A spokesman for Ali said in a statement earlier Thursday that the former heavyweight champion is being treated at an unidentified hospital for a respiratory issue. Spokesman Bob Gunnell said Ali was in fair condition, and a brief hospital stay was expected. Gunnell said in an email Friday there was no update on Ali’s condition.

Ali’s longtime Parkinson’s doctor declined comment when reached by the AP Thursday night.

“I can’t really say much more than what’s in the papers,” said Dr. Abraham Lieberman of the Barrow Neurological Institute in Phoenix.

Ali has been hospitalized several times in recent years, most recently in early 2015 when he was treated for a severe urinary tract infection initially diagnosed as pneumonia.

Ali has looked increasingly frail in public appearances, including April 9 when he wore sunglasses and was hunched over at the annual Celebrity Fight Night dinner in Phoenix, which raises funds for treatment of Parkinson’s.

His last formal public appearance before that was in October when he appeared at the Sports Illustrated Tribute to Muhammad Ali at The Muhammad Ali Center in his hometown of Louisville, Kentucky, along with former opponents George Foreman and Larry Holmes.

Ali has suffered from Parkinson’s for three decades, most famously trembling badly while lighting the Olympic torch in 1996 in Atlanta. Despite the disease he kept up a busy appearance schedule until recently, though he has not spoken in public for years.

Doctors say the Parkinson’s likely was caused by the thousands of punches Ali took during a career in which he traveled the world for big fights.

An iconic figure who at one point was perhaps the most recognized person in the world, Ali has lived quietly in the Phoenix area with his fourth wife, Lonnie, whom he married in 1986.

News of his hospitalization brought well wishes from boxers and others on Twitter, including Sugar Ray Leonard, who modeled his career after Ali’s.

“Prayers & blessings to my idol, my friend, & without question, the Greatest of All Time @MuhammadAli ! #GOAT,” Leonard wrote.