Orsillo wasn’t offered a new contract with NESN, and will be replaced by Dave O’Brien. Orsillo first broadcast Red Sox games on NESN in 2001 and became the full-time play-by-play man in 2005 when the network acquired rights to all local telecasts.

“Don is an outstanding broadcaster, and we are grateful for all of his contributions to NESN’s telecast over the years,” NESN President and CEO Sean McGrail said in a statement. “On behalf of everyone at NESN and the Boston Red Sox organization, we would like to extend our sincere appreciation to Don.”

O’Brien, currently part of Boston’s radio broadcast team, is expected to continue calling college basketball games for ESPN.

Alongside Jerry Remy, Orsillo broadcast games for World Series championship teams in 2004, 2007 and 2013.

“I’m truly going to miss him on a personal side and he’s become a very close friend of mine,” Remy told The Boston Globe.