INDIANAPOLIS (AP) — Andrew Luck threw for three touchdowns and ran for another Sunday night, outplaying predecessor Peyton Manning in a 39-33 victory over the previously unbeaten Denver Broncos.

The victory ended the Broncos’ 17-game regular-season winning streak in the first game Manning played against his former team since being released in March 2012.

Manning finished 29 of 49 for 386 yards with three TDs and one interception. He was sacked four times and tried desperately to rally the Broncos (6-1) late.

But the Colts (5-2) took advantage of his and Denver’s uncharacteristic mistakes.

Luck converted an early fumble into a TD pass. Indy got nine points out of a second-quarter strip sack, and Luck scored on a 10-yard run in the third quarter, a drive helped by a series of defensive penalties. When the Broncos finally had a chance to tie it, Manning was intercepted.

Indianapolis has not lost consecutive games under Luck.