Ortiz entered the night tied with Harold Baines for the most hits as a DH and it took just one at-bat to claim the record. Ortiz doubled to left-center field to lead off the second inning and was acknowledged by a standing ovation from the mix of Red Sox and Mariners fans.

An inning later, Ortiz collected his eighth hit of the series with a two-run homer off Seattle starter Aaron Harang (4-8), his 19th this season.

Jacoby Ellsbury had three hits to extend his hitting streak to 18 games, currently the best in baseball, and the Red Sox knocked around Harang for seven runs and eight hits.

Ortiz appeared touched by the ovation, tipping his helmet twice toward the standing fans and patting his chest. Ortiz already held the marks for the most runs scored, doubles, home runs, extra-base hits and RBIs by a designated hitter.

Ortiz scored in the second on Jared Saltalamacchia’s sacrifice fly, then provided the big blow in the third with a two-out, two-run homer to right-center field, his second straight game going deep.

Boston broke the game open in the sixth and knocked out Harang after singles by Jose Iglesias and Brock Holt to open the inning. Ellsbury and Shane Victorino both had RBI singles in the four-run inning that was helped along by a throwing error from Seattle shortstop Brad Miller.

After Seattle held a 5-1 lead after two innings in Tuesday’s game, the Red Sox have outscored the Mariners 21-7 in the following 16 innings.

Ortiz’s milestone night overshadowed one of the best starts this season by Boston’s Felix Doubront. With its bullpen taxed in the opening two games of the series, Doubront (6-3) provided the outing Boston needed to give its relievers a rest.

Doubront took a shutout into the seventh and silenced a Seattle offense that scored 19 runs against Boston pitching in the first two games of the series. He allowed only a pair of early singles, and a double to Michael Saunders — the first Seattle batter to reach second base — in the fifth.

Seattle finally got to Doubront in the seventh when Jason Bay led off with a double and scored on Henry Blanco’s two-out single. But that was the extent of Seattle’s offense against the lefty. Doubront won his second straight start after going more than a month without a victory. It was third time this season Doubront has allowed one earned run or less, and just the second time he’s finished seven innings.

Doubront struck out six and walked two.

Notes: Seattle SS Brendan Ryan led off the eighth with a solo homer off Boston’s Brandon Workman, making his major league debut. Seattle scored three times in the inning. … Ellsbury returned after missing the first two games of the series with a sore wrist. … Seattle RHP Stephen Pryor (60-day DL, lat muscle), threw a 25-pitch simulated game on Wednesday and will do the same on Saturday. Manager Eric Wedge said OFs Michael Morse (quad) and Franklin Gutierrez (hamstring) are not yet ready to go out on rehab assignments. … Boston manager John Farrell said RHP Alex Wilson, placed on the 15-day DL Tuesday, has joint inflammation in his thumb, but the injury is not as serious as first believed.